Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.
نویسندگان
چکیده
منابع مشابه
Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.
Wild-type (Agt+/+) and homozygous angiotensinogen deletion mutant (Agt-/-) littermates were placed on normal (NS) or low Na diet (LS) for 2 weeks. Plasma aldosterone levels (P(aldo)) were comparable during NS, and similarly elevated during LS in Agt+/+ and Agt-/-. Moreover, in both, the elevation in P(aldo) was accompanied by marked increase in adrenal zona glomerulosa cells and adrenal P450ald...
متن کاملDynamics of extracellular fluid volume changes during hyperproteinemia.
The dynamics of fluid volume distribution between the blood and interstitium during hyperproteinemia were studied in 12 anephric, conscious dogs during several states of hydration. After recovery from splenectomy and unilateral nephrectomy, plasma protein concentration was elevated to 8.4-8.7 g/dl by daily intravenous infusion of 330 ml of previously collected autologous plasma for 11 days. The...
متن کاملMechanisms Regulating Aldosterone Secretion during Sodium Depletion.
BINNION, PETER F., JAMES 0. DAVIS, TORREY C. BROWN, AND MICHAEL J. OLICHNEY. Mechanisms regulating aldosterone secretion during sodium depletion. Am. J. Physiol. 208(4) : 655-661. rg65.LSteroid secretion was studied in conscious dogs before and during 4 days of Na depletion. A threefold increase in aldosterone secretion occurred but corticosterone output was unchanged. Plasma renin was markedly...
متن کاملDynamics of extracellular fluid volume changes during hyperproteinemia
Manning, R. Davis, Jr. Dynamics of extracellular fluid volume changes during hyperproteinemia. Am. J. Physiol. 275 (Regulatory Integrative Comp. Physiol. 44): R1878– R1884, 1998.—The dynamics of fluid volume distribution between the blood and interstitium during hyperproteinemia were studied in 12 anephric, conscious dogs during several states of hydration. After recovery from splenectomy and u...
متن کاملThe renin-angiotensin system and aldosterone secretion during sodium depletion in the rat.
The role of the renin-angiotensin system in the control of aldosterone secretion was studied in the sodium-depleted rat. Administration of angiotensin II produced a significant increase in aldosterone secretion and arterial blood pressure in normal rats; simultaneous infusion of the angiotensin analogue, l-sarcosine-8-alanine-angiotensin II, blocked both the pressor and the steroidogenic action...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119249